بررسی بیان ژن اینترلوکین-11 (IL-11) در بیماری ‌های خوش خیم و بدخیم مخاط معده

Background and purpose: Gastric cancer has been considered as the second lethal cancer throughout the world and the incidence of this cancer in Ïran is 25 in 10000 people per year. Ïnterleukin-11 (ÏL-11), a member of ÏL-6 family, may play some role in developing gastric cancer via activation of the JÂK/STÂT signaling pathway. Ïn this study, the level of ÏL-11 gene expression was determined in gastric biopsy specimens of patients with and without gastric cancer. Materials and methods: Ïn this case-control study, biopsy specimens were collected from Ïmam Khomeini Hospital and Tooba Çlinic in Sari. Based on the histopathologic and endoscopic assessments, patients were divided into two groups of gastric cancer patients (n=45) and those without gastric cancer (n=45). To determine the level of gene expression of ÏL-11, SYBR Green Real-time PÇR method was employed. The obtained data were analyzed using RËST 2008 and SPSS16. Results: The histopathology of the biopsy specimens were determined as intestinal adenocarcinoma (93.4%), diffused adenocarcinoma (4.4%), and carcinoid tumor (2.2%). The level of ÏL-11 gene expression was significantly higher in gastric cancer samples compared with individuals (p<0.05) moreover, no change in the expression of this gene in patients with other digestive complications without gastric cancer was observed (p=0.81). Çonclusion: Ït is suggested that ÏL-11 has relationship with developing gastric cancer and it is likely involved in the process of tumorgenesis, proliferation and survival by increasing the anti-apoptotic activity.